Gruppi di Lavoro


	Copyright 2007© ASMA -All Right Reserved-	Ultimo aggiornamento:

Gruppi di lavoro 2007

INDICE

1. Definizione, meccanismi e fisiopatologia

Braido, Beghè, Fontana, Pellegrino

2. Epidemiologia e fattori di rischio

Carrozzi, D'Amato

3. Diagnosi e classificazione

- importanza della spirometria nella diagnosi e monitoraggio

- l'asma intermittente

4. Terapia farmacologica dell'adulto

Dente, Antonicelli, Liccardi, Paggiaro

5. L'asma del bambino

- differenze fisiopatologiche

- terapia farmacologica

- l'asma da esercizio fisico

6. L'educazione e la prevenzione

Foschino, Infantino, Neri, Tesi

7. Le riacutizzazioni

- meccanismi

- terapia

1. Definizione, meccanismi e fisiopatologia	INDICE

1) Kiley J, Smith R, Noel P: Asthma phenotypes. Curr Opin Pulm Med. 2007 Jan;13(1):19-23. 2) Heaton T, Rowe J, Turner S, Aalberse RC, de Klerk N, Suriyaarachchi D, Serralha M, Holt BJ, Hollams E, Yerkovich S, Holt K, Sly PD, Goldblatt J, Le Souef P, Holt PG: An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet. 2005 Jan 8-14;365(9454):142-9 3) Holgate ST, Polosa R: The mechanisms, diagnosis, and management of severe asthma in adults. Lancet. 2006 Aug 26;368(9537):780-93. 4) Umetsu DT: Revising the immunological theories of asthma and allergy. Lancet. 2005 Jan 8-14;365(9454):98-100.

2. Epidemiologia e fattori di rischio	INDICE

1) D'Amato G, Bucchioni E, Oldani V, Canonica W.: Treating Moderate-to-Severe Allergic Asthma with a Recombinant Humanized Anti-IgE Monoclonal Antibody (Omalizumab). Treat Respir Med. 2006;5(6):393-8. 2) D'Amato G, Liccardi G, Frenguelli G: Thunderstorm-asthma and pollen allergy. Allergy. 2007 Jan;62(1):11-6. 3) Dockery WDe Stone PH "Cardiovascular risks from fine particulate air pollution" NEJM 2007;356:512-3 4) Miller KA et al: Long-term exposure to air pollution and incidence of cardiovascular events in women.NEJM2007;356:447-58 5) The politics of breathing.Nature 2006;444:248-9

3. Diagnosi e classificazione	INDICE

1) Appleton SL, Adams RJ, Wilson DH, Taylor AW, Ruffin RE; North West Adelaide Cohort Health Study Team: Spirometric criteria for asthma: adding further evidence to the debate. J Allergy Clin Immunol. 2005 Nov;116(5):976-82. 2) Fuhlbrigge AL, Weiss ST, Kuntz KM, Paltiel AD; CAMP Research Group: Forced expiratory volume in 1 second percentage improves the classification of severity among children with asthma. Pediatrics. 2006 Aug;118(2):e347-55. Epub 2006 Jul 24. 3) Gelb AF, Flynn Taylor C, Shinar CM, Gutierrez C, Zamel N: Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. Chest. 2006 Jun;129(6):1492-9. 4) Leuppi JD, Dieterle T, Wildeisen I, Martina B, Tamm M, Koch G, Perruchoud AP, Leimenstoll BM: Can airway obstruction be estimated by lung auscultation in an emergency room setting? Respir Med. 2006 Feb;100(2):279-85. 5) Lusuardi M, De Benedetto F, Paggiaro P, Sanguinetti CM, Brazzola G, Ferri P, Donner CF: A randomized controlled trial on office spirometry in asthma and COPD in standard general practice: data from spirometry in Asthma and COPD: a comparative evaluation Italian study. Chest. 2006 Apr;129(4):844-52.

4. Terapia farmacologica dell'adulto	INDICE

1) Strunk RC, and Bloomberg GR: Omalizumab for Asthma. N Engl J Med 2006;354:2689-95. 2) Salpeter SR, Buckley NS, Ormiston TM, and Salpeter EE: Meta-Analysis: Effect of Long-Acting -Agonists on Severe Asthma Exacerbations and Asthma-Related Deaths. Ann Intern Med. 2006;144:904-912. 3) Adams NP, Jones PW: The dose–response characteristics of inhaled corticosteroids when used to treat asthma: An overview of Cochrane systematic reviews. Respiratory Medicine (2006) 100, 1297–1306 4) Chinchilli VM: General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting b-agonists. 5) Nowak D: Management of asthma with anti-immunoglobulin E: A review of clinical trials of omalizumab. Respiratory Medicine (2006) 100, 1907–1917 6) Gibson PG, Powell H, N Engl J Med. 2006 May 11;354(19):1985-97ferential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations. J Allergy Clin Immunol. 2007 Feb;119(2):344-350 7) Marceau C, Lemiere C, Berbiche D, Perreault S, Blais L. Persistence, adherence, and effectiveness of combination therapy among adult patients with asthma. J Allergy Clin Immunol. 2006 Sep;118(3):574-81 8) Blumberga G, Groes L, Haugaard L, Dahl R.: Steroid-sparing effect of subcutaneous SQ-standardised specific immunotherapy in moderate and severe house dust mite allergic asthmatics. Allergy. 2006 Jul;61(7):843-8. 9) Calamita Z, Saconato H, Pela AB, Atallah AN: Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006 Oct;61(10):1162-72. 10) Cox LS, Linnemann DL, Nolte H, Weldon D, Finegold I, Nelson HS: Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol. 2006 May;117(5):1021-35 11) Winther L, Arnved J, Malling HJ, Nolte H, Mosbech H: Side-effects of allergen-specific immunotherapy: a prospective multi-centre study. Clin Exp Allergy. 2006 Mar;36(3):254-60. 12) Maestrelli P, Zanolla L, Pozzan M, Fabbri LM; Regione Veneto Study Group on the "Effect of immunotherapy in allergic asthma":Effect of specific immunotherapy added to pharmacologic treatment and allergen avoidance in asthmatic patients allergic to house dust mite. J Allergy Clin Immunol. 2004 Apr;113(4):643-9. 13) Nelson HS: Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol. 2007 Feb 8 14) Niggemann B, Jacobsen L, Dreborg S, Ferdousi HA, Halken S, Host A, Koivikko A, Koller D, Norberg LA, Urbanek R, Valovirta E, Wahn U, Moller C; PAT Investigator Group: Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy. 2006 Jul;61(7):855-9 15) Pham-Thi N, Scheinmann P, Fadel R, Combebias A, Andre C: Assessment of sublingual immunotherapy efficacy in children with house dust mite-induced allergic asthma optimally controlled by pharmacologic treatment and mite-avoidance measures. Pediatr Allergy Immunol. 2007 Feb;18(1):47-57. 16) Liccardi G, Passalacqua G: Sensitization to rabbit allergens in Italy--a multicentre study in atopic subjects without occupational exposure. Int Arch Allergy Immunol. 2006;141(3):295-9. 17) Nopp A, Johansson SG, Lundberg M, Oman H: Simultaneous exposure of several allergens has an additive effect on multisensitized basophils. Allergy. 2006 Nov;61(11):1366-8 18) Liccardi G, Piccolo A, Dente B, Salzillo A, Noschese P, Gilder JA, Russo M, D'Amato G: Rabbit allergens: A significant risk for allergic sensitization in subjects without occupational exposure. Respir Med. 2007 Feb;101(2):333-9. Epub 2006 Nov 28 19) Salo PM, Arbes SJ Jr, Sever M, Jaramillo R, Cohn RD, London SJ, Zeldin DC: Exposure to Alternaria alternata in US homes is associated with asthma symptoms. J Allergy Clin Immunol. 2006 Oct;118(4):892-8. 20) Liccardi G, D'Amato G: Drugs may also induce allergic reactions in sensitized individuals through passionate kissing. J Allergy Clin Immunol. 2007 Jan 24; 21) Zeidler MR, Goldin JG, Kleerup EC, Kim HJ, Truong DA, Gjertson DW, Kennedy NJ, Newman KB, Tashkin DP, Silverman JM, Corren J: Small airways response to naturalistic cat allergen exposure in subjects with asthma. J Allergy Clin Immunol. 2006 Nov;118(5):1075-81. 22) Busse WW, Mitchell H: Addressing issues of asthma in inner-city children. J Allergy Clin Immunol. 2007 Jan;119(1):43-9

5. L'asma del bambino	INDICE

1) Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F: Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med. 2006 May 11;354(19):1998-2005 2) Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, Bacharier LB, Lemanske RF Jr, Strunk RC, Allen DB, Bloomberg GR, Heldt G, Krawiec M, Larsen G, Liu AH, Chinchilli VM, Sorkness CA, Taussig LM, Martinez FD: Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med. 2006 May 11;354(19):1985-97 3) De Benedictis FM, Del Giudice MM, Forenza N, Decimo F, De Benedictis D, Capristo A: Lack of tolerance to the protective effect of montelukast in exercise-induced bronchoconstriction in children. Eur Respir J. 2006 Aug;28(2):291-5 4) Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Panizzolo C, Zanin ME, Zuin R, Maestrelli P, Fabbri LM, Saetta M: Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med. 2006 Nov 1;174(9):975-81 5) Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A, IFWIN study team: Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet. 2006 Aug 26;368(9537):754-62. 6) Robertson CF, Price D, Henry R, Mellis C, Glasgow N, Fitzgerald D, Lee AJ, Turner J, Sant M: Short-course montelukast for intermittent asthma in children: a randomized controlled trial. Am J Respir Crit Care Med. 2007 Feb 15;175(4):323-9 7) Saglani S, Molyneux C, Gong H, Rogers A, Malmstrom K, Pelkonen A, Makela M, Adelroth E, Bush A, Payne DN, Jeffery PK: Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants. Eur Respir J. 2006 Sep;28(3):505-12. 8) Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Chinchilli VM,Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Bloomberg GR, Covar RA, Guilbert TW, Heldt G, Larsen G, Mellon MH, Morgan WJ, Moss MH, Spahn JD, Taussig LM;the Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute: Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 2007 Jan;119(1):64-72

6. L'educazione e la prevenzione	INDICE

1) Written individualised management plans for asthma in children and adults (Review) Cochrane Database of Systematic Reviews 2004, Issue 1. 2) Buist AS, Vollmer WM, Wilson SR, Frazier EA, and Hayward AD: A Randomized Clinical Trial of Peak Flow versus Symptom Monitoring in Older Adults with Asthma. Am J Respir Crit Care Med. 2006 Nov 15;174(10):1077-87 3) David A. Beuther E. Rand Sutherland Overweight, Obesity and Incident Asthma: A Meta-analysis of Prospective Epidemiologic Studies. Am J Respir Crit Care Med. 2007 Jan 18 4) Bratton SL, Cabana MD, Brown RW, White DF, Wang Y, Lang SW, Clark NM: Asthma educational seminar targeting Medicaid providers. Respir Care. 2006 Jan;51(1):49-55. 5) Baddar S, Worthing EA, Al-Rawas OA, Osman Y, Al-Riyami BM: Compliance of physicians with documentation of an asthma management protocol. Respir Care. 2006 Dec;51(12):1432-40. 6) Saini B, Smith L, Armour C, Krass I: An educational intervention to train community pharmacists in providing specialized asthma care. Am J Pharm Educ. 2006 Oct 15;70(5):118 7) Holgate ST, Price D, Valovirta E.: Asthma out of control? A structured review of recent patient surveys. BMC Pulm Med. 2006 Nov 30;6 Suppl 1:S2.

7. Le riacutizzazioni	INDICE

GINA (Global INitiative for Asthma) è protetto dalle leggi e dalle regolazioni sul copyright internazionale e sui marchi registrati. Il nome, il logo e il materiale ad esso collegato non può essere copiato, riprodotto o estratto in nessuna maniera senza previa autorizzazione di GINA.